Lipsky H, Würnschimmel E
Department of Urology, Landeskrankenhaus, Leoben, Austria.
Br J Urol. 1993 Dec;72(6):965-8. doi: 10.1111/j.1464-410x.1993.tb16311.x.
Submucosal injections of bovine collagen (Zyplast) were administered to 67 children and 7 adults with 115 refluxing ureters. Reflux was grade I in 14 ureters, grade II in 54, grade III in 38 and grade IV in 9. All patients had a history of recurrent urinary infection. One year after treatment 70 ureters showed no reflux, 20 were grade I and 25 showed a complete recurrence. The cure rate was 81% if grade I recurrence is included. In all, 68 ureters were followed up for 2 to 4 years. In 19 ureters a second injection was given, 47 showed no reflux, 19 had grade I reflux and 2 had a recurrence. In 5 ureters reflux grade I disappeared without a second injection. The cure rate was 97%. Renal scarring was seen in 4 kidneys. Collagen injections are an adequate method of treatment for reflux grades I-III.
对67名儿童和7名成人的115条反流性输尿管进行了黏膜下注射牛胶原蛋白（Zyplast）治疗。14条输尿管为Ⅰ级反流，54条为Ⅱ级，38条为Ⅲ级，9条为Ⅳ级。所有患者均有复发性尿路感染病史。治疗1年后，70条输尿管无反流，20条为Ⅰ级，25条完全复发。若将Ⅰ级复发包括在内，治愈率为81%。共有68条输尿管随访了2至4年。19条输尿管进行了第二次注射，47条无反流，19条为Ⅰ级反流，2条复发。5条输尿管Ⅰ级反流未进行第二次注射就消失了。治愈率为97%。4个肾脏出现了肾瘢痕形成。胶原蛋白注射是治疗Ⅰ - Ⅲ级反流的一种适当方法。
