Ahlenius S, Engel J, Lundborg P
Naunyn Schmiedebergs Arch Pharmacol. 1975;288(2-3):185-93. doi: 10.1007/BF00500526.
The acquisition of a conditioned avoidance response (CAR) was investigated in rats of nursing mothers given pimozide 0.5 mg/kg on days 1, 2, 3, 4, 5, 6, and 7 after delivery. Four weeks after birth, the male litter-mates were tested for CAR acquisition in a two-way avoidance situation or for correct CAR acquisition in a brightness discrimination situation. Offspring of mothers treated with pimozide were markedly inferior in the CAR acquisition in both behavioural situations as compared to those of mothers given glucose. The administration of d-amphetamine 15 min prior to the training session specifically counteracted the behavioural impairment obtained in the offspring of pimozide-treated mothers. The results obtained in the present investigation lend further support to the contention that the behavioural deficits in offspring of nursing mothers treated with neuroleptic agents are due to a developmental disturbance in central catecholamine neurones.
对分娩后第1、2、3、4、5、6和7天给予0.5mg/kg匹莫齐特的哺乳母鼠的子代大鼠进行了条件性回避反应（CAR）习得的研究。出生四周后，对雄性同窝幼崽在双向回避情境中进行CAR习得测试，或在亮度辨别情境中进行正确CAR习得测试。与给予葡萄糖的母鼠的子代相比，接受匹莫齐特治疗的母鼠的子代在两种行为情境中的CAR习得均明显较差。在训练前15分钟给予d-苯丙胺可特异性抵消匹莫齐特治疗母鼠子代中出现的行为损伤。本研究获得的结果进一步支持了以下观点，即接受抗精神病药物治疗的哺乳母鼠子代的行为缺陷是由于中枢儿茶酚胺神经元的发育障碍所致。
