1] Shanghai-Ministry of Science and Technology Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China. [2].
Nat Genet. 2013 Oct;45(10):1168-75. doi: 10.1038/ng.2757. Epub 2013 Sep 8.
Cystic echinococcosis (hydatid disease), caused by the tapeworm E. granulosus, is responsible for considerable human morbidity and mortality. This cosmopolitan disease is difficult to diagnose, treat and control. We present a draft genomic sequence for the worm comprising 151.6 Mb encoding 11,325 genes. Comparisons with the genome sequences from other taxa show that E. granulosus has acquired a spectrum of genes, including the EgAgB family, whose products are secreted by the parasite to interact and redirect host immune responses. We also find that genes in bile salt pathways may control the bidirectional development of E. granulosus, and sequence differences in the calcium channel subunit EgCavβ1 may be associated with praziquantel sensitivity. Our study offers insights into host interaction, nutrient acquisition, strobilization, reproduction, immune evasion and maturation in the parasite and provides a platform to facilitate the development of new, effective treatments and interventions for echinococcosis control.
棘球蚴病（包虫病）由带绦虫细粒棘球绦虫引起，给人类造成了相当大的发病率和死亡率。这种世界性疾病难以诊断、治疗和控制。我们提供了该虫的基因组序列草图，大小为 151.6Mb，编码 11325 个基因。与其他分类群的基因组序列比较表明，细粒棘球绦虫获得了一系列基因，包括 EgAgB 家族，其产物由寄生虫分泌，以相互作用并重新定向宿主免疫反应。我们还发现，胆盐途径中的基因可能控制细粒棘球绦虫的双向发育，钙通道亚基 EgCavβ1 的序列差异可能与吡喹酮敏感性有关。我们的研究提供了对寄生虫中宿主相互作用、营养获取、稳定化、繁殖、免疫逃避和成熟的深入了解，并为开发新的、有效的治疗和干预措施来控制包虫病提供了一个平台。
