阿尔茨海默病和朊病毒病：PDK1 在十字路口。

Alzheimer's and prion diseases: PDK1 at the crossroads.

机构信息

Institut de Pharmacologie Moléculaire et Cellulaire, UMR7275 CNRS/Université Nice Sophia-Antipolis, Laboratory of Excellence "DISTALZ," Valbonne, France.

出版信息

Nat Med. 2013 Sep;19(9):1088-90. doi: 10.1038/nm.3332.

DOI:10.1038/nm.3332

PMID:24013743

Abstract

TACE-mediated proteolysis is a key event interfering with both Alzheimer's and prion diseases. A new study shows that phosphoinositide-dependent kinase-1 (PDK1) is activated by cellular prion protein, which alters membrane-associated TACE levels, thereby influencing both Alzheimer's and prion pathologies.

摘要

TACE 介导的蛋白水解是干扰阿尔茨海默病和朊病毒病的关键事件。一项新的研究表明，磷酸肌醇依赖性激酶-1（PDK1）被细胞朊病毒蛋白激活，这改变了与膜相关的 TACE 水平，从而影响阿尔茨海默病和朊病毒病的病理。