Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Chicago, Illinois, USA, and the Department of Neurobiology, Northwestern University, Evanston, Illinois, USA.
Nat Med. 2013 Sep;19(9):1090-2. doi: 10.1038/nm.3334.
The fibroblast growth factor 21 (FGF21)-β-Klotho pathway orchestrates a switch to oxidative metabolism during fasting and starvation and has been implicated as a signal connecting nutrition, growth, reproduction and longevity. Two new studies in mice show that Fgf21 interacts directly with the brain circadian clock to coordinate activity and reproduction as part of the adaptation to fasting.
成纤维细胞生长因子 21 (FGF21)-β-Klotho 途径在禁食和饥饿期间协调向氧化代谢的转变,并被认为是连接营养、生长、繁殖和长寿的信号。两项新的小鼠研究表明,Fgf21 与大脑昼夜节律直接相互作用,以协调活动和繁殖,作为对禁食适应的一部分。