Mak Calvin H K, Wong Stephen K H, Wong George K, Ng Stephanie, Wang Kevin K W, Lam Ping Kuen, Poon Wai Sang
Division of Neurosurgery, Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
Curr Transl Geriatr Exp Gerontol Rep. 2012 Jul 6;1(3):171-178. doi: 10.1007/s13670-012-0017-2. eCollection 2012.
Traumatic brain injury in elderly patients is a neglected global disease burden. The main cause is fall, followed by motor vehicle accidents. This review article summarizes different aspects of geriatric traumatic brain injury, including epidemiology, pathology, and effects of comorbidities and pre-injury medications such as antiplatelets and anticoagulants. Functional outcome with or without surgical intervention, cognitive outcome, and psychiatric complications are discussed. Animal models are also reviewed in attempt to explain the relationship of aging and outcome, together with advances in stem cell research. Though elderly people in general did fare worse after traumatic brain injury, certain "younger elderly" people, aged 65-75 years, could have a comparable outcome to younger adults after minor to moderate head injury.
老年患者的创伤性脑损伤是一种被忽视的全球疾病负担。主要原因是跌倒，其次是机动车事故。这篇综述文章总结了老年创伤性脑损伤的不同方面，包括流行病学、病理学，以及合并症和伤前用药（如抗血小板药和抗凝剂）的影响。讨论了有无手术干预的功能结局、认知结局和精神并发症。还综述了动物模型，试图解释衰老与结局的关系，以及干细胞研究的进展。尽管一般来说，老年人在创伤性脑损伤后情况更糟，但某些65至75岁的“年轻老年人”在轻度至中度头部受伤后，其结局可能与年轻成年人相当。
