Child and Adolescent Psychiatry Department, Mersin University School of Medicine, 33079, Mersin, Turkey,
Int J Hematol. 2013 Oct;98(4):430-6. doi: 10.1007/s12185-013-1422-9. Epub 2013 Sep 8.
In this study, we aimed to investigate the prevalence and associated factors of nocturnal enuresis in sickle cell disease (SCD) and thalassemia major (TM) patients in a single center from Turkey. One hundred and six patients, 51 (48.1 %) with TM and 55 (51.9 %) with SCD, and 80 age-matched healthy controls were included in the study. Semi-structured interviews were conducted with the caregivers of pediatric and adult patients. The interview included questions on nocturnal enuresis and psychosocial variables. Patients' hospital files were reviewed to search for disease-related factors. Twenty-eight of the patients (26.4 %) and three (3.7 %) of the controls had nocturnal enuresis. Younger age, TM diagnosis, family history of nocturnal enuresis and family problems were found to be more frequent in patients with nocturnal enuresis. Among the patients with SCD, frequencies of hospitalization and painful crises were found to be higher in those with enuresis. According to the binary logistic regression analysis, diagnosis of TM (p = 0.031, OR = 0.262) and younger age (p = 0.005, OR = 0.869) were found to be independent risk factors for nocturnal enuresis in the patient group. Nocturnal enuresis is a common problem in children and young adults with TM and SCD. Associated factors in both conditions will be clarified with future studies.
在这项研究中，我们旨在调查土耳其单一中心的镰状细胞病 (SCD) 和重型地中海贫血 (TM) 患者夜间遗尿症的患病率和相关因素。研究纳入了 106 名患者，其中 51 名（48.1%）为 TM 患者，55 名（51.9%）为 SCD 患者，80 名年龄匹配的健康对照者。对儿科和成年患者的照顾者进行了半结构化访谈。访谈包括夜间遗尿症和社会心理变量的问题。查阅了患者的病历，以寻找与疾病相关的因素。28 名患者（26.4%）和 3 名对照者（3.7%）有夜间遗尿症。在遗尿症患者中，年龄较小、TM 诊断、夜间遗尿症家族史和家庭问题更为常见。在 SCD 患者中，遗尿症患者的住院和疼痛危象频率更高。根据二元逻辑回归分析，TM 诊断（p = 0.031，OR = 0.262）和年龄较小（p = 0.005，OR = 0.869）是患者组夜间遗尿症的独立危险因素。夜间遗尿症是 TM 和 SCD 儿童和年轻患者常见的问题。未来的研究将阐明两种情况下的相关因素。
