铜催化的多米诺环加成/C-N 偶联/环化/(C-H 芳基化)：一种高效的氮多杂环化合物的三组分合成方法。
Copper-catalyzed domino cycloaddition/C-N coupling/cyclization/(C-H arylation): an efficient three-component synthesis of nitrogen polyheterocycles.
机构信息
Department of Medicinal Chemistry, Amgen Inc. One Amgen Center Drive, Thousand Oaks, CA 91320-1799 (USA).
出版信息
Angew Chem Int Ed Engl. 2013 Oct 11;52(42):10992-6. doi: 10.1002/anie.201305970. Epub 2013 Sep 6.
PMID:24014265
Abstract
A cat of all trades: A single copper catalyst promoted up to three reaction steps with separate catalytic cycles in a domino sequence (azide-alkyne cycloaddition/Goldberg amidation/Camps cyclization/(CH arylation)) for the rapid construction of complex heterocycles from three simple components under mild conditions. Facile cleavage of the triazole ring enables further elaboration of the condensation products.
摘要
万能猫
单一铜催化剂在级联反应中（叠氮-炔环加成反应/戈尔伯格酰胺化反应/坎普斯环化反应/（CH 芳基化反应）中促进了三个具有独立催化循环的反应步骤，可在温和条件下，快速从三个简单组分构建复杂杂环。三唑环的易断裂特性使其能够进一步衍生缩合产物。
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