抗群体感应淬灭化合物。
Resistance to quorum-quenching compounds.
机构信息
Instituto Nacional de Cardiología, Departamento de Bioquímica, Tlalpan, Mexico City, Mexico.
出版信息
Appl Environ Microbiol. 2013 Nov;79(22):6840-6. doi: 10.1128/AEM.02378-13. Epub 2013 Sep 6.
Abstract
Bacteria have the remarkable ability to communicate as a group in what has become known as quorum sensing (QS), and this trait has been associated with important bacterial phenotypes, such as virulence and biofilm formation. Bacteria also have an incredible ability to evolve resistance to all known antimicrobials. Hence, although inhibition of QS has been hailed as a means to reduce virulence in a manner that is impervious to bacterial resistance mechanisms, this approach is unlikely to be a panacea. Here we review the evidence that bacteria can evolve resistance to quorum-quenching compounds.
摘要
细菌具有作为一个群体进行交流的显著能力，这种能力被称为群体感应（QS），这种特性与细菌的重要表型有关，例如毒力和生物膜形成。细菌还具有令人难以置信的能力来对抗所有已知的抗菌药物产生耐药性。因此，尽管抑制 QS 被吹捧为一种降低毒力的方法，这种方法不受细菌耐药机制的影响，但这种方法不太可能是万无一失的。在这里，我们回顾了细菌可以对群体感应淬灭化合物产生耐药性的证据。
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