Elmesseri Rana A, Saleh Sarra E, Elsherif Heba M, Yahia Ibrahim S, Aboshanab Khaled M
Department of Microbiology, Faculty of Pharmacy, Misr International University (MIU), Cairo 19648, Egypt.
Department of Microbiology & Immunology, Faculty of Pharmacy, Ain Shams University (ASU), Cairo 11566, Egypt.
Antibiotics (Basel). 2022 Feb 23;11(3):298. doi: 10.3390/antibiotics11030298.
is a fatal Gram-positive pathogen threatening numerous cases of hospital-admitted patients worldwide. The emerging resistance of the pathogen to several antimicrobial agents has pressurized research to propose new strategies for combating antimicrobial resistance. Novel strategies include targeting the virulence factors of . One of the most prominent virulence factors of is its eponymous antioxidant pigment staphyloxanthin (STX), which is an auspicious target for anti-virulence therapy. This review provides an updated outline on STX and multiple strategies to attenuate this virulence factor. The approaches discussed in this article focus on bioprospective and chemically synthesized inhibitors of STX, inter-species communication and genetic manipulation. Various inhibitor molecules were found to exhibit appreciable inhibitory effect against STX and hence would be able to serve as potential anti-virulence agents for clinical use.
是一种致命的革兰氏阳性病原体，威胁着全球众多住院患者。该病原体对多种抗菌药物产生的新耐药性促使研究提出对抗抗菌药物耐药性的新策略。新策略包括针对的毒力因子。最突出的毒力因子之一是其同名抗氧化色素葡萄球菌黄素（STX），它是抗毒力治疗的一个理想靶点。本综述提供了关于STX的最新概述以及多种减弱该毒力因子的策略。本文讨论的方法集中在STX的生物勘探和化学合成抑制剂、种间通讯和基因操作。发现各种抑制剂分子对STX表现出明显的抑制作用，因此有望作为潜在的临床抗毒力药物。
