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Am J Physiol Lung Cell Mol Physiol. 2013 Nov 1;305(9):L595-603. doi: 10.1152/ajplung.00212.2013. Epub 2013 Sep 6.
Ion channels perform a variety of cellular functions in lung epithelia. Oxidant- and antioxidant-mediated mechanisms (that is, redox regulation) of ion channels are areas of intense research. Significant progress has been made in our understanding of redox regulation of ion channels since the last Experimental Biology report in 2003. Advancements include: 1) identification of nonphagocytic NADPH oxidases as sources of regulated reactive species (RS) production in epithelia, 2) an understanding that excessive treatment with antioxidants can result in greater oxidative stress, and 3) characterization of novel RS signaling pathways that converge upon ion channel regulation. These advancements, as discussed at the 2013 Experimental Biology Meeting in Boston, MA, impact our understanding of oxidative stress in the lung, and, in particular, illustrate that the redox state has profound effects on ion channel and cellular function.
离子通道在肺上皮细胞中执行多种细胞功能。离子通道的氧化剂和抗氧化剂介导的机制（即氧化还原调节）是研究的热点领域。自 2003 年上次实验生物学报告以来，我们对离子通道的氧化还原调节的理解取得了重大进展。这些进展包括：1）鉴定非吞噬性 NADPH 氧化酶作为上皮细胞中受调节的活性物质（RS）产生的来源，2）了解到过量使用抗氧化剂会导致更大的氧化应激，以及 3）描述新型 RS 信号通路，这些通路汇聚于离子通道调节。这些进展，如在马萨诸塞州波士顿举行的 2013 年实验生物学会议上所讨论的那样，影响了我们对肺部氧化应激的理解，特别是说明了氧化还原状态对离子通道和细胞功能有深远的影响。
