Meltzer H Y, Burnett S, Bastani B, Ramirez L F
Case Western Reserve University School of Medicine, Cleveland, Ohio 44106.
Hosp Community Psychiatry. 1990 Aug;41(8):892-7. doi: 10.1176/ps.41.8.892.
The effect of approximately six months of treatment with clozapine on the quality of life of 38 treatment-resistant schizophrenic patients was prospectively studied in an open trial. The Quality of Life Scale was used to provide an objective measure of changes in patients' psychosocial functioning. Significant improvement was noted on all four factors of the scale. The ratings tended to be negatively correlated with ratings on the Brief Psychiatric Rating Scale at baseline and at six months. At 12 months, patients' rehospitalization rate was reduced by 83 percent and was independent of the six-month quality-of-life ratings.
在一项开放性试验中，对38例难治性精神分裂症患者进行了为期约六个月的氯氮平治疗，并对其生活质量进行了前瞻性研究。使用生活质量量表对患者心理社会功能的变化进行客观测量。量表的所有四个因素均有显著改善。在基线和六个月时，这些评分与简明精神病评定量表的评分呈负相关。在12个月时，患者的再住院率降低了83%，且与六个月的生活质量评分无关。
