甲泼尼龙对卵巢切除并同时给予间羟甲酪氨酸抑制内源性肾上腺素大鼠骨丢失及骨密度的影响

Effect of methylprednisolone on bone mineral density in rats with ovariectomy-induced bone loss and suppressed endogenous adrenaline levels by metyrosine.

机构信息

Department of Obstetrics and Gynecology, Ataturk University, Faculty of Medicine, Erzurum, Turkey.

出版信息

Indian J Pharmacol. 2013 Jul-Aug;45(4):344-7. doi: 10.4103/0253-7613.115008.

DOI:10.4103/0253-7613.115008

PMID:24014908

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3757601/

Abstract

OBJECTIVES

In this study, effect of methylprednisolone on bone mineral density (BMD) was investigated in rats with overiectomy induced bone lose and suppressed endogenous adrenalin levels, and compared to alendronate.

MATERIALS AND METHODS

Severity of bone loss in the examined material (femur bones) was evaluated by BMD measurement.

RESULTS

The group with the highest BMD value was metyrosinemetyrosine + methylprednisolone combination (0.151 g/cm(2)), while that with the lowest BMD was methylprednisolone (0.123 g/cm(2)). Alendronate was effective only when used alone in ovariectomized rats (0.144 g/cm(2)), but not when used in combination with methylprednisolone (0.124 g/cm(2)). In the ovariectomized rat group which received only metyrosine, BMD value was statistically indifferent from ovariectomized control group.

CONCLUSIONS

Methylprednisolone protected bone loss in rats with suppressed adrenaline levels because of metyrosinemetyrosine.

摘要

目的

在本研究中，通过比较甲泼尼龙和阿仑膦酸钠，研究了甲泼尼龙对去卵巢导致的骨丢失和内源性肾上腺素水平抑制的大鼠的骨密度（BMD）的影响。

材料和方法

通过 BMD 测量评估检查材料（股骨）的骨丢失严重程度。

结果

甲泼尼龙联合蛋氨酸（0.151g/cm²）组的 BMD 值最高，而甲泼尼龙（0.123g/cm²）组的 BMD 值最低。阿仑膦酸钠仅在单独用于去卵巢大鼠时有效（0.144g/cm²），而与甲泼尼龙联合使用时无效（0.124g/cm²）。在仅接受蛋氨酸的去卵巢大鼠组中，BMD 值与去卵巢对照组无统计学差异。