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盐酸曲马多：一种新型镇痛药。

Tapentadol hydrochloride: A novel analgesic.

作者信息

Singh Dewan Roshan, Nag Kusha, Shetti Akshaya N, Krishnaveni N

机构信息

Department of Anaesthesiology and Critical Care, Mahatma Gandhi Medical College, Pillaiyarkuppam, Pondicherry, India.

出版信息

Saudi J Anaesth. 2013 Jul;7(3):322-6. doi: 10.4103/1658-354X.115319.

DOI:10.4103/1658-354X.115319
PMID:24015138
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3757808/
Abstract

Tapentadol is a novel, centrally acting analgesic with dual mechanism of action, combining mu-opioid receptor agonism with noradrenaline reuptake inhibition in the same molecule. It has an improved side effect profile when compared to opioids and nonsteroidal anti-inflammatory drugs. The dual mechanism of action makes Tapentadol a useful analgesic to treat acute, chronic, and neuropathic pain.

摘要

曲马多是一种新型的中枢性镇痛药，具有双重作用机制，在同一分子中结合了μ-阿片受体激动作用和去甲肾上腺素再摄取抑制作用。与阿片类药物和非甾体抗炎药相比，它具有更好的副作用谱。双重作用机制使曲马多成为治疗急性、慢性和神经性疼痛的有效镇痛药。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a56/3757808/51bebb704711/SJA-7-322-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a56/3757808/51bebb704711/SJA-7-322-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a56/3757808/51bebb704711/SJA-7-322-g001.jpg

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Indian J Anaesth. 2011 Mar;55(2):101-3. doi: 10.4103/0019-5049.79872.
2
Tapentadol in pain management: a μ-opioid receptor agonist and noradrenaline reuptake inhibitor.曲马多在疼痛管理中的应用：μ-阿片受体激动剂和去甲肾上腺素再摄取抑制剂。
CNS Drugs. 2011 May;25(5):359-70. doi: 10.2165/11589080-000000000-00000.
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Tapentadol immediate release: a new treatment option for acute pain management.酒石酸布托啡诺即释片：急性疼痛管理的新治疗选择。
慢性疼痛患者的药物治疗与治疗药物监测
Pharmaceutics. 2023 Aug 5;15(8):2088. doi: 10.3390/pharmaceutics15082088.
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Novel Natrosol/Pectin-co-poly (acrylate) based pH-responsive polymeric carrier system for controlled delivery of Tapentadol Hydrochloride.用于盐酸曲马多控释的新型基于羟丙基甲基纤维素/果胶共聚丙烯酸酯的pH响应聚合物载体系统。
Saudi Pharm J. 2023 Aug;31(8):101671. doi: 10.1016/j.jsps.2023.06.004. Epub 2023 Jun 12.
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Neuropathic pain: Mechanisms and therapeutic strategies.神经性疼痛：机制与治疗策略。
Front Cell Dev Biol. 2023 Jan 16;11:1072629. doi: 10.3389/fcell.2023.1072629. eCollection 2023.
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Patient Perceptions and Potential Utility of Pharmacogenetic Testing in Chronic Pain Management and Opioid Use Disorder in the Camden Opioid Research Initiative.卡姆登阿片类药物研究计划中患者对药物遗传学检测在慢性疼痛管理和阿片类药物使用障碍中的认知及潜在效用
Pharmaceutics. 2022 Sep 3;14(9):1863. doi: 10.3390/pharmaceutics14091863.
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Multimechanistic Single-Entity Combinations for Chronic Pain Control: A Narrative Review.用于慢性疼痛控制的多机制单一实体组合：一项叙述性综述。
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J Pain Res. 2010 Feb 8;3:1-9. doi: 10.2147/jpr.s4989.
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Cost-effectiveness analysis of tapentadol immediate release for the treatment of acute pain.酒石酸布托啡诺透皮贴剂治疗中重度慢性非癌痛的药物经济学评价
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In vitro and in vivo characterization of tapentadol metabolites.曲马多代谢物的体外和体内特性研究。
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