胰岛素抵抗的分子基础：胰岛素受体底物（IRS）和叉头框蛋白O1（Foxo1）在糖尿病及其并发症控制中的作用
Molecular Basis of Insulin Resistance: The Role of IRS and Foxo1 in the Control of Diabetes Mellitus and Its Complications.
作者信息
Guo Shaodong
机构信息
Division of Molecular Cardiology, Cardiovascular Research Institute, College of Medicine, Texas A&M University Health Science Center, Scott & White; Central Texas Veterans Health Care System, Temple, TX 76504, USA.
出版信息
Drug Discov Today Dis Mech. 2013 Jun 1;10(1-2):e27-e33. doi: 10.1016/j.ddmec.2013.06.003.
Abstract
Insulin/IGF-1 signaling plays a central role in control of cellular metabolism and survival, while insulin receptor substrate (IRS) protein -1 and -2 and downstream PI-3 kinase→Akt→Foxo1 signaling cascade play key roles in many functions of insulin/IGF-1. Dysregulation of this branch of signaling cascades may provide a mechanism for insulin resistance as we observed in cells, animals, and even humans. Targeting this branch of IRS→Foxo1 signaling may provide us with fundamental strategies for drug development in the future.
摘要
胰岛素/胰岛素样生长因子-1信号传导在细胞代谢和存活的调控中起核心作用，而胰岛素受体底物（IRS）蛋白-1和-2以及下游的PI-3激酶→Akt→Foxo1信号级联在胰岛素/胰岛素样生长因子-1的许多功能中起关键作用。正如我们在细胞、动物甚至人类中所观察到的，这一信号级联分支的失调可能为胰岛素抵抗提供一种机制。针对IRS→Foxo1信号传导这一分支可能为我们未来的药物开发提供基本策略。
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