Srivastava V M, Agarwal N, Visen P K, Katiyar J C
Division of Biochemistry, Central Drug Research Institute, Lucknow, India.
Indian J Exp Biol. 1990 Jun;28(6):578-81.
Dicarboxylic acids and a few amino acids were found to support mitochondrial phosphorylation in A. ceylanicum. Anaerobiasis markedly reduced this activity. Maximum effect was observed on succinate supported phosphorylation which in anaerobic atmosphere yielded only 2% ATP compared to that in the presence of air. Known as well as candidate anthelmintics significantly inhibited ATP formation. Mebendazole, amongst them, registered greatest effect. Oxygen consumption by the mitochondria exhibited poor response to the action of anthelmintics other than praziquantel.
在锡兰钩虫中发现二羧酸和一些氨基酸可支持线粒体磷酸化。厌氧状态显著降低了这种活性。观察到对琥珀酸支持的磷酸化有最大影响，在厌氧环境中产生的ATP仅为有氧环境下的2%。已知的以及候选的驱虫药显著抑制ATP的形成。其中，甲苯达唑的效果最为显著。除吡喹酮外，线粒体的氧消耗对其他驱虫药的作用反应不佳。
