Srivastava J K, Gupta S, Katiyar J C, Srivastava V M
Indian J Exp Biol. 1989 Aug;27(8):735-8.
Effects of methyl [5[[4-(2-pyridinyl)-1-piperazinyl] carbonyl] 1H-benzimidazol-2-yl] carbamate (CDRI Comp. 81-470) and mebendazole on the energy metabolism of A. ceylanicum and N. brasiliensis were compared. At 10 and 50 microM concentration both compounds inhibited glucose uptake and its conversion into metabolic endproducts. The shift towards the increased production of lactic acid appeared to be the result of inhibition of PEP carboxykinase and increase in LDH activity. The compounds also caused significant inhibition of ATP production in mitochondria.
比较了甲基[5[[4-(2-吡啶基)-1-哌嗪基]羰基]1H-苯并咪唑-2-基]氨基甲酸酯（CDRI化合物81-470）和甲苯达唑对锡兰钩虫和巴西钩虫能量代谢的影响。在10和50微摩尔浓度下，这两种化合物均抑制葡萄糖摄取及其向代谢终产物的转化。乳酸产量增加的转变似乎是磷酸烯醇式丙酮酸羧激酶受到抑制和乳酸脱氢酶活性增加的结果。这些化合物还显著抑制线粒体中的ATP生成。
