Wing R R, Shoemaker M, Marcus M D, McDermott M, Gooding W
University of Pittsburgh School of Medicine, PA.
Int J Obes. 1990 Jun;14(6):495-503.
Because weight loss is difficult to achieve, it would be helpful to determine whether there are subgroups of obese type II diabetic patients who benefit most from participation in a behavioral weight loss program. We studied 178 obese patients with type II diabetes, who participated in a 12-20 week behavioral weight loss program and were followed for 1 year after the program to determine whether age, gender, percent overweight, medication, duration of diabetes or fasting glucose were related to weight loss and/or to the magnitude of improvement in glycemic control experienced with weight loss. Gender was the only variable related to weight loss; males lost more weight and had greater decreases in percent overweight than females. The variable most strongly related to improvement in glycemic control was pretreatment fasting glucose level; patients with higher initial glucose levels experienced the greatest improvements in control. There was no evidence to support the belief that patients on insulin have poorer weight losses or that patients with long-duration diabetes benefit less from weight reduction than those with recent-onset diabetes.
由于减肥很难实现，因此确定肥胖的II型糖尿病患者中是否有亚组能从参与行为减肥计划中获益最大将很有帮助。我们研究了178例肥胖的II型糖尿病患者，他们参加了为期12 - 20周的行为减肥计划，并在该计划结束后随访1年，以确定年龄、性别、超重百分比、药物治疗、糖尿病病程或空腹血糖是否与体重减轻和/或减肥过程中血糖控制改善的程度相关。性别是与体重减轻相关的唯一变量；男性比女性减重更多，超重百分比下降幅度更大。与血糖控制改善最密切相关的变量是治疗前空腹血糖水平；初始血糖水平较高的患者在血糖控制方面改善最大。没有证据支持以下观点：使用胰岛素的患者减肥效果较差，或者糖尿病病程长的患者比近期发病的患者从减肥中获益更少。
