精神病患者血浆催乳素水平与氯丙嗪之间的相关性。
Correlation between plasma levels of prolactin and chlorpromazine in psychiatric patients.
作者信息
Kolakowska T, Wiles D H, McNeilly A S, Gelder M G
出版信息
Psychol Med. 1975 May;5(2):214-6. doi: 10.1017/s0033291700056488.
PMID:240179
Abstract
Plasma levels of chlorpromazine (CPZ) and prolactin were measured repeatedly in 14 psychiatric patients throughout CPZ treatment. Mean prolactin level was elevated in 11 subjects (all six women and five of eight men). Mean plasma prolactin correlated significantly with mean plasma CPZ but not with the dose of the drug. Only patients with mean plasma prolactin above 35 ng/ml developed Parkinsonian side-effects.
摘要
在14名精神病患者接受氯丙嗪（CPZ）治疗的全过程中，对其血浆中氯丙嗪（CPZ）水平和催乳素水平进行了多次测量。11名受试者（6名女性全部及8名男性中的5名）的平均催乳素水平升高。平均血浆催乳素与平均血浆CPZ显著相关，但与药物剂量无关。只有平均血浆催乳素高于35 ng/ml的患者出现帕金森氏症副作用。
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