Oscarsson J, Carlsson-Bostedt L, Carlsson L, Stigbrand T, von Schoultz B, Edén S
Department of Physiology, University of Göteborg, Sweden.
J Reprod Fertil. 1990 Jul;89(2):717-22. doi: 10.1530/jrf.0.0890717.
Continuous infusion of bovine GH to hypophysectomized non-pregnant rats increased serum concentrations of pregnancy-associated murine protein-1 (PAMP-1) to the levels of adult female rats and pregnant rats. Serum concentrations of PAMP-1 were followed from Day 16 of gestation until 3 days after parturition in hypophysectomized (on Day 14 of gestation) and intact pregnant rats. In the intact pregnant rat there was a decrease in PAMP-1 values from Day 16 until delivery. The serum concentrations of PAMP-1 in hypophysectomized pregnant rats were similar to those in intact pregnant rats before parturition, but PAMP-1 concentrations decreased markedly after parturition in the hypophysectomized rats. We suggest that the serum concentrations of PAMP-1 can be maintained without pituitary GH in late pregnancy, while serum values of PAMP-1 in non-pregnant rats is dependent upon a continuous secretion of pituitary GH.
向垂体切除的未孕大鼠持续输注牛生长激素，可使妊娠相关小鼠蛋白-1（PAMP-1）的血清浓度升高至成年雌性大鼠和妊娠大鼠的水平。在垂体切除（妊娠第14天）的妊娠大鼠和正常妊娠大鼠中，从妊娠第16天开始跟踪PAMP-1的血清浓度，直至分娩后3天。在正常妊娠大鼠中，从第16天到分娩，PAMP-1值下降。垂体切除的妊娠大鼠分娩前PAMP-1的血清浓度与正常妊娠大鼠相似，但垂体切除的大鼠分娩后PAMP-1浓度显著下降。我们认为，妊娠晚期PAMP-1的血清浓度在无垂体生长激素的情况下也可维持，而非妊娠大鼠的PAMP-1血清值则依赖于垂体生长激素的持续分泌。
