Rodriguez R M, Fernandez A F, Fraga M F
Cancer Epigenetics Laboratory, Instituto Universitario de Oncología del Principado de Asturias (IUOPA-HUCA), Universidad de Oviedo, Oviedo, Spain.
Genes Cancer. 2013 Mar;4(3-4):105-11. doi: 10.1177/1947601913479798.
Sirtuins play an essential role in the cellular response to environmental stress, promoting DNA repair, telomere stability, cell cycle arrest, cellular senescence, and apoptosis. Much attention has been given to the role of sirtuins in aging and cancer development; however, less is known about their role in stem cell regulation. This review focuses in this topic and discusses the possible implications in adult stem cell aging.
沉默调节蛋白在细胞对环境应激的反应中发挥着重要作用，促进DNA修复、端粒稳定性、细胞周期停滞、细胞衰老和细胞凋亡。人们对沉默调节蛋白在衰老和癌症发展中的作用给予了很多关注；然而，它们在干细胞调节中的作用却鲜为人知。本综述聚焦于这一主题，并讨论其在成体干细胞衰老中的潜在影响。
