大观霉素在大鼠体内的药代动力学特征。
Pharmacokinetic profile of spectinomycin in rats.
作者信息
Madhura D B, Lee R, Meibohm B
机构信息
Department of Pharmaceutical Sciences, University of Tennessee Health Sciences Center, 881 Madison Ave, Suite 444, Memphis, TN 38163, USA.
出版信息
Pharmazie. 2013 Aug;68(8):675-6.
Abstract
Following intravenous (IV) administration, the pharmacokinetics of spectinomycin in rats was found to be on par with its profile in other mammalian species including humans with respect to its overall excretion and half-life at effective concentrations. This study, however, indicates that a small fraction of the spectinomycin dose is retained in peripheral tissues for a prolonged period of time at low concentrations.
摘要
静脉注射给药后，已发现大观霉素在大鼠体内的药代动力学，就其在有效浓度下的总体排泄和半衰期而言，与包括人类在内的其他哺乳动物物种的情况相当。然而，这项研究表明，一小部分大观霉素剂量会在低浓度下长时间保留在外周组织中。
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本文引用的文献
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