Davies J, Anderson P, Davis B D
Science. 1965 Sep 3;149(3688):1096-8. doi: 10.1126/science.149.3688.1096.
Spectinomycin selectively inhibits protein synthesis in cells and in extracts of Escherichia coli. Mutations to high-level resistance to this antibiotic map close to the streptomycin locus, and the site of action of spectinomycin, like that of streptomycin, is the 30S ribosomal subunit, as shown by experiments with reconstituted 70S ribosomes containing subunits from sensitive and from resistant ribosomes. In contrast to streptomycin, however, spectinomycin is not bactericidal and causes no detectable misreading of polyribonucleotides.
壮观霉素可选择性抑制细胞及大肠杆菌提取物中的蛋白质合成。对这种抗生素产生高水平抗性的突变定位于靠近链霉素基因座的位置，并且如用含有敏感核糖体亚基和抗性核糖体亚基重构的70S核糖体所做实验表明，壮观霉素的作用位点与链霉素一样，都是30S核糖体亚基。然而，与链霉素不同的是，壮观霉素无杀菌作用，也不会导致多聚核糖核苷酸出现可检测到的错读。
