Rutkowska M, Trocha M, Szandruk M, Słupski W, Rymaszewska J
Department of Pharmacology, Medical University, Wroclaw, Poland.
Pharmazie. 2013 Aug;68(8):685-8.
Polyunsaturated fatty acids play an important role in the human organism. They guarantee a normal function of nervous cells, influence neurotransmission, and build some elements of cellular membranes. Several reports indicate an association between a deficiency of polyunsaturated fatty acids and depression. The aim of this study was to examine the effects of diet supplemented with fish oil, which is rich in omega-3 polyunsaturated fatty acids (n-3 PUFAs) and n-3 PUFAs enriched phospholipids ("super lecithin") obtained from designed eggs on anhedonic-like response and body weight in the rat chronic mild stress (CMS) model of depression. The results showed that neither fish oil nor n-3 PUFAs enriched egg yolk phospholipids supplementation reversed disturbances caused by CMS, such as anhedonic-like state or reduction of body weight gain.
多不饱和脂肪酸在人体中起着重要作用。它们保证神经细胞的正常功能，影响神经传递，并构成细胞膜的一些成分。几份报告表明多不饱和脂肪酸缺乏与抑郁症之间存在关联。本研究的目的是检测在大鼠慢性轻度应激（CMS）抑郁模型中，补充富含ω-3多不饱和脂肪酸（n-3 PUFAs）的鱼油和从特制鸡蛋中获得的富含n-3 PUFAs的磷脂（“超级卵磷脂”）的饮食对快感缺失样反应和体重的影响。结果表明，补充鱼油或富含n-3 PUFAs的蛋黄磷脂均不能逆转由CMS引起的紊乱，如快感缺失样状态或体重增加减少。
