Grigorenko D Ye, Aminova G G, Sapin M R
Institute of Morphology, RAMS, Moscow, Russia
Morfologiia. 2013;143(3):54-8.
Structural organization of the duodenal wall was studied in older men (aged 70-75 years, n=15), and its lymphoid tissue was examined using the qualitative and quantitative analysis. Deformation, flattening and sparseness of the intestinal villi were identified. Atrophic phenomena in the organ mucous membrane were accompanied by the destruction of the cells of surface epithelium, crypts and glands. Simultaneous infiltration of the lamina propria with lymphocytes, eosinophils, neutrophils and malfunctions in a microcirculatory bed is indicative of the presence of inflammatory processes. The duodenum of the elderly persons was characterized by the disruption of the integrity of the lamina muscularis mucosae that lead to the displacement of the duodenal glands from submucosa to the lamina propria. The suppression of cell proliferative activity, decreased blast transformation activity, in the lymphoid tissue of the intestine, along with a high degree of cell destruction, lead to the weakening of local immunity in the elderly persons.
对老年男性（70 - 75岁，n = 15）的十二指肠壁结构组织进行了研究，并采用定性和定量分析方法对其淋巴组织进行了检查。发现肠绒毛有变形、变平和稀疏现象。器官黏膜的萎缩现象伴有表面上皮、隐窝和腺体细胞的破坏。固有层同时出现淋巴细胞、嗜酸性粒细胞、中性粒细胞浸润以及微循环床功能障碍，表明存在炎症过程。老年人的十二指肠特点是黏膜肌层完整性破坏，导致十二指肠腺从黏膜下层移位至固有层。肠道淋巴组织中细胞增殖活性受抑制、母细胞转化活性降低，以及高度的细胞破坏，导致老年人局部免疫力减弱。
