Watson Lea C, Esserman Denise A, Ivey Jena L, Lewis Carmen L, Hansen Richard, Weinberger Morris, Roth Mary T
Department of Psychiatry, UNC School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Division of General Medicine and Clinical Epidemiology, UNC School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC; Department of Biostatistics, UNC Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Am J Geriatr Psychiatry. 2014 Sep;22(9):884-8. doi: 10.1016/j.jagp.2013.01.075. Epub 2013 Sep 8.
To pilot a pharmacist-led, patient centered medication management program.
Prospective, single arm trial.
Academic geriatric psychiatry outpatient clinic.
Outpatients at least 65 years old, proxy available if demented, and on two or more psychiatric medications.
A clinical pharmacist completed a baseline medication review and made evidence-based recommendations that were implemented by the pharmacist after discussion with the physician. The pharmacist made a minimum of monthly contact for 6 months to review medications and related issues.
The primary outcome was the change in number of medication related problems over time (3 and 6 months) as defined by a predetermined classification system.
The mean age of the 27 patients was 75 years, 10 of whom required a proxy to participate. On average, patients had nine chronic conditions and were taking 14 medications. The mean number (SD; range) of medication related problems at baseline was 4.1 (2.2; 0-8) and at 3 and 6 months were 3.6 (2.4, 0-9) and 3.4 (2.1; 0-8), respectively. Most follow-up problems were new (80% and 89% at 3 and 6 months, respectively).
Using a pharmacist to deliver a medication management program was feasible and addressed existing problems. New problems, however, developed over a short interval (3-6 months), suggesting that ongoing intervention is required.
试行一项由药剂师主导、以患者为中心的药物管理项目。
前瞻性单臂试验。
学术性老年精神病学门诊诊所。
年龄至少65岁的门诊患者,若为痴呆患者则需有代理人,且正在服用两种或更多种精神科药物。
临床药剂师完成基线药物审查,并提出循证建议,经与医生讨论后由药剂师实施。药剂师至少每月联系一次,持续6个月,以审查药物及相关问题。
主要结局是根据预定分类系统定义的随时间推移(3个月和6个月)药物相关问题数量的变化。
27名患者的平均年龄为75岁,其中10名患者需要代理人参与。患者平均患有9种慢性病,服用14种药物。基线时药物相关问题的平均数量(标准差;范围)为4.1(2.2;0 - 8),3个月和6个月时分别为3.6(2.4,0 - 9)和3.4(2.1;0 - 8)。大多数随访问题是新出现的(3个月和6个月时分别为80%和89%)。
利用药剂师开展药物管理项目是可行的,且解决了现有问题。然而,新问题在短时间内(3 - 至6个月)出现,这表明需要持续干预。