Department of Gynecology and Obstetrics, Emory University School of Medicine, 49 Jesse Hill Jr Drive, Atlanta, GA 30303, USA.
Obstet Gynecol Clin North Am. 2013 Sep;40(3):475-512. doi: 10.1016/j.ogc.2013.05.009. Epub 2013 Jul 30.
An understanding of the diagnosis and clinical management of hereditary breast and ovarian cancer syndrome (HBOC) is essential for obstetricians/gynecologists. This article provides practical information regarding collecting a family history, cancer risk assessment and genetic testing, BRCA-associated cancer prognosis and treatment, screening recommendations, and prevention strategies. Through appropriate cancer risk assessment, women with BRCA1/2 mutations can be identified, and screening and prevention strategies can be used before a diagnosis of cancer occurs. Women's health providers with a strong working knowledge of HBOC are able to improve the quality of care for women and families impacted by BRCA1/2 mutations.
了解遗传性乳腺癌和卵巢癌综合征 (HBOC) 的诊断和临床管理对于妇产科医生来说至关重要。本文提供了有关收集家族史、癌症风险评估和基因检测、BRCA 相关癌症预后和治疗、筛查建议和预防策略的实用信息。通过适当的癌症风险评估，可以识别出携带 BRCA1/2 突变的女性，并在癌症诊断前使用筛查和预防策略。对 HBOC 有深入了解的女性健康提供者能够提高受 BRCA1/2 突变影响的女性和家庭的护理质量。
