血清碱性磷酸酶和磷酸盐与脑梗死后脑动脉粥样硬化和功能结局的关系。
Serum alkaline phosphatase and phosphate in cerebral atherosclerosis and functional outcomes after cerebral infarction.
机构信息
From the Department of Neurology, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea (J.K.); Department of Neurology, Ewha Womans University, Seoul, Republic of Korea (T.-J.S.); and Departments of Neurology (J.K., D.S., H.S.N., Y.D.K., J.H.H.) and Biostatistics (H.S.L., C.M.N.), Yonsei University College of Medicine, Seoul, Republic of Korea.
出版信息
Stroke. 2013 Dec;44(12):3547-9. doi: 10.1161/STROKEAHA.113.002959. Epub 2013 Sep 10.
BACKGROUND AND PURPOSE
Higher serum alkaline phosphatase (ALP) and phosphate levels are associated with atherosclerotic disease and an increased risk of cardiovascular events. However, the association of ALP/phosphate with cerebral atherosclerosis and prognosis in patients with acute stroke is not well known.
METHODS
In 1034 patients with first-ever acute cerebral infarction, levels of ALP and phosphate were compared with (1) cerebral atherosclerosis and (2) poor long-term functional outcomes as defined by the modified Rankin Scale>2 at 3 months after stroke onset.
RESULTS
ALP levels were not associated with cerebral atherosclerosis. However, higher levels of ALP were associated with a poor functional outcome (adjusted odds ratio per 1 SD, 1.25; 95% confidence interval, 1.04-1.50). Phosphate was associated with neither cerebral atherosclerosis nor functional outcome.
CONCLUSIONS
A higher level of ALP was not associated with cerebral atherosclerosis but was an independent prognostic factor for long-term functional outcome after acute cerebral infarction.
背景与目的
血清碱性磷酸酶（ALP）和磷酸盐水平升高与动脉粥样硬化疾病和心血管事件风险增加有关。然而，ALP/磷酸盐与急性脑卒中患者的脑动脉粥样硬化和预后的关系尚不清楚。
方法
在 1034 例首次发生急性脑梗死的患者中，比较了 ALP 和磷酸盐水平与（1）脑动脉粥样硬化和（2）卒中发病后 3 个月改良 Rankin 量表评分>2 定义的不良长期功能结局之间的关系。
结果
ALP 水平与脑动脉粥样硬化无关。然而，较高的 ALP 水平与不良的功能结局相关（调整后的优势比每 1 SD，1.25；95%置信区间，1.04-1.50）。磷酸盐与脑动脉粥样硬化或功能结局均无关。
结论
较高的 ALP 水平与脑动脉粥样硬化无关，但与急性脑梗死患者的长期功能结局是独立的预后因素。
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