Department of Surgery, Steinberg-Bernstein Centre for Minimally Invasive Surgery and Innovation, McGill University Health Centre, Montreal, Canada.
J Surg Res. 2014 Jan;186(1):135-41. doi: 10.1016/j.jss.2013.08.006. Epub 2013 Aug 28.
The Gastrointestinal Quality of Life Index (GIQLI) is a disease-specific quality of life instrument that is commonly used in gastrointestinal disorders. However, no preference weights, which are used to calculate quality-adjusted life years for cost-effectiveness analyses, for this instrument have been assigned. Therefore, the objective of this study was to develop a mapping function to derive utility scores for the GIQLI.
Patients undergoing elective laparoscopic cholecystectomy completed the short-form 6D (SF-6D), a preference-weighted utility measure, and the GIQLI at baseline and at 1 wk and 1 mo postoperatively. The responsiveness of the SF-6D to expected postoperative changes as well as the correlation between the SF-6D and the GIQLI was investigated. Ordinary least squares regression was performed to derive a mapping function using the baseline values, which was then validated using postoperative values. Adjusted r(2), mean absolute error, and root mean square error was used to determine model performance.
A total of 50 patients were included in the study (mean age 51.1 [standard deviation 16.8], 28% male). The SF-6D and GIQLI domains were responsive to expected postoperative changes, and there was high correlation between the SF-6D and four of the five GIQLI domains (excluding treatment effects). The final mapping function explained 63% of the variance in the derivation sample but had relatively high mean absolute error (0.075 and 0.067 in the 1-wk and 1-mo samples, respectively) and adjusted root mean square error (13.1% and 12.0% in the 1-wk and 1-mo samples, respectively).
The GIQLI can be accurately mapped to SF-6D preference weights at the group level but may be too inexact at the individual level.
胃肠道生活质量指数（GIQLI）是一种常用于胃肠道疾病的特定于疾病的生活质量工具。然而，对于这种仪器，尚未分配用于成本效益分析的质量调整生命年的偏好权重。因此，本研究的目的是开发一种映射函数，以得出 GIQLI 的效用得分。
接受择期腹腔镜胆囊切除术的患者在基线、术后 1 周和 1 个月时完成了简短 6 维度（SF-6D）、偏好加权效用衡量标准和 GIQLI。研究了 SF-6D 对预期术后变化的反应能力以及 SF-6D 与 GIQLI 的相关性。使用基线值进行普通最小二乘回归以得出映射函数，然后使用术后值进行验证。使用调整后的 r（2）、平均绝对误差和均方根误差来确定模型性能。
共纳入 50 例患者（平均年龄 51.1 [标准差 16.8]，28%为男性）。SF-6D 和 GIQLI 域对预期的术后变化敏感，SF-6D 与 GIQLI 的四个域（不包括治疗效果）之间存在高度相关性。最终的映射函数在推导样本中解释了 63%的方差，但平均绝对误差相对较高（1 周和 1 个月样本分别为 0.075 和 0.067），调整后的均方根误差也较高（1 周和 1 个月样本分别为 13.1%和 12.0%）。
GIQLI 可以在组水平上准确映射到 SF-6D 偏好权重，但在个体水平上可能不够精确。
