脑电图异常与记忆门诊队列中脑脊液生物标志物的相关性。
Association between EEG abnormalities and CSF biomarkers in a memory clinic cohort.
机构信息
Department of Neurobiology, Care Sciences and Society, University Medical Centre Ljubljana, Ljubljana, Slovenia.
出版信息
Dement Geriatr Cogn Disord. 2013;36(5-6):319-28. doi: 10.1159/000351677. Epub 2013 Sep 10.
BACKGROUND
The aim of the study was to describe distinct electroencephalogram (EEG) phenotypes defined after routine visual EEG analysis in a large memory clinic cohort and to investigate their relationship to cerebrospinal fluid (CSF) biomarkers.
METHODS
Patients with Alzheimer's disease (n = 131), mild cognitive impairment (n = 285), subjective cognitive impairment (n = 310), and mixed dementia (n = 29) were assessed clinically with neuroimaging, EEG and CSF investigations. EEG phenotypes were based on frequency of background activity (BA) and presence and degree of episodic abnormalities (EA).
RESULTS
BA and EA differed significantly (p < 0.001) between diagnostic groups. A lower CSF amyloid β42/phospho-tau ratio and higher total tau were associated with slower BA (p < 0.01) and a higher degree of EA (p < 0.04).
CONCLUSIONS
Slowing of BA in combination with EA seems to be related to biological markers of neurodegeneration.
背景
本研究旨在描述在大型记忆诊所队列中经过常规视觉脑电图分析后定义的不同脑电图表型，并探讨其与脑脊液（CSF）生物标志物的关系。
方法
对阿尔茨海默病（n = 131）、轻度认知障碍（n = 285）、主观认知障碍（n = 310）和混合性痴呆（n = 29）患者进行神经影像学、脑电图和 CSF 检查。脑电图表型基于背景活动（BA）的频率和发作异常（EA）的存在和程度。
结果
BA 和 EA 在诊断组之间存在显著差异（p < 0.001）。较低的 CSF 淀粉样蛋白β42/磷酸化 tau 比值和较高的总 tau 与较慢的 BA（p < 0.01）和更高程度的 EA（p < 0.04）相关。
结论
BA 减慢与 EA 相结合似乎与神经退行性变的生物标志物有关。
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