Department of Neurology, University of Kentucky College of Medicine, Lexington, 40536, USA.
Curr Neurol Neurosci Rep. 2013 Oct;13(10):380. doi: 10.1007/s11910-013-0380-1.
Infective endocarditis is an infection of the inner surface or endocardium of the heart, in most instances involving the heart valves or the mural portion of the endocardium. As nonbacterial organisms such as rickettsia, fungi, and even viruses may also cause endocarditis, the term "infective endocarditis" is preferred over the older terminology of "bacterial endocarditis." Despite advancements in medical treatment and surgical therapies over the last few decades, infective endocarditis continues to be associated with a poor prognosis. There are many different factors affecting the clinical outcome in patient with infective endocarditis, including the type of organism and its virulence, patient characteristics, comorbid illness, time to diagnosis and treatment, indications for surgery, and time to surgery when indicated. In this article, we will review the epidemiology of endocarditis, the neurologic complications of infective endocarditis, and the current therapeutic strategies.
感染性心内膜炎是心脏内膜内层或心内膜的感染，多数情况下涉及心脏瓣膜或心内膜的壁层部分。由于立克次体、真菌甚至病毒等非细菌性生物体也可能引起心内膜炎，因此“感染性心内膜炎”这个术语比旧的“细菌性心内膜炎”术语更受欢迎。尽管在过去几十年中，医学治疗和外科治疗取得了进展，但感染性心内膜炎仍然与预后不良相关。许多不同的因素会影响感染性心内膜炎患者的临床结果，包括病原体的类型和毒力、患者特征、合并症、诊断和治疗时间、手术指征以及在需要时进行手术的时间。在本文中，我们将回顾心内膜炎的流行病学、感染性心内膜炎的神经系统并发症以及当前的治疗策略。
