Baluta Monica Mariana, Benea Elisabeta Otilia, Stanescu Cristina Maria, Vintila Marius Marcian
"Carol Davila" University of Medicine, Cardiology Department "St Pantelimon" Hospital, Bucharest, Romania.
Maedica (Bucur). 2011 Oct;6(4):290-7.
Endocarditis still carries a poor prognosis despite improvement in preventive strategies and advances in diagnosis and also in treatment. Epidemiology of infective endocarditis (IE) has changed in late years. Contemporary antibiotic overuse determines antibiotic resistance against microorganisms involved in IE. Prophylaxis principles have been changed and restricted in order to avoid excessive antibiotic use and unfounded costs. Current guidelines are often based on expert opinion because of the low incidence of the disease, the absence of randomized trials, and the limited number of meta-analyses. The present review will focus on current changes in epidemiology, prophylaxis, diagnosis and treatment options.
尽管在预防策略、诊断及治疗方面都取得了进展，但心内膜炎的预后仍然很差。近年来，感染性心内膜炎（IE）的流行病学发生了变化。当代抗生素的过度使用导致了对IE相关微生物的耐药性。为避免抗生素过度使用和不必要的费用，预防原则已有所改变并受到限制。由于该疾病发病率低、缺乏随机试验以及荟萃分析数量有限，当前指南往往基于专家意见。本综述将聚焦于流行病学、预防、诊断及治疗选择方面的当前变化。
