钌催化的乙酰苯胺与芳香酸的氧化邻苯甲酰化反应。
Ruthenium-catalyzed oxidative ortho-benzoxylation of acetanilides with aromatic acids.
机构信息
Department of Chemistry, Indian Institute of Science Education and Research, Pune 411021, India.
出版信息
Chem Commun (Camb). 2013 Oct 25;49(83):9651-3. doi: 10.1039/c3cc45350b.
PMID:24022697
Abstract
Substituted acetanilides reacted with aromatic acids in the presence of [{RuCl2(p-cymene)}2], AgSbF6 and (NH4)2S2O8 in ClCH2CH2Cl at 100 °C for 24 h yielding ortho-benzoxylated acetanilides in good to excellent yields in a highly regioselective manner via C-H bond activation.
摘要
取代乙酰苯胺与芳香酸在[RuCl2(p-cymene)]2、AgSbF6 和 (NH4)2S2O8 的存在下，于 100°C 在 ClCH2CH2Cl 中反应 24 小时，通过 C-H 键活化以高产率至优异产率得到邻苯甲酰化乙酰苯胺，具有高度区域选择性。
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