钌催化乙酰苯胺与芳基硼酸的邻位芳基化反应：一种简便的制备菲啶和咔唑的方法。
Ruthenium-catalyzed ortho-arylation of acetanilides with aromatic boronic acids: an easy route to prepare phenanthridines and carbazoles.
机构信息
Department of Chemistry, Indian Institute of Science Education and Research, Pune 411021, India.
出版信息
Chem Commun (Camb). 2014 Mar 7;50(19):2442-4. doi: 10.1039/c3cc49398a. Epub 2014 Jan 22.
PMID:24452525
Abstract
The highly regioselective ortho-arylation of acetanilides with aromatic boronic acids in the presence of a Ru(II) complex (3 mol%), AgSbF6 (12 mol%), Cu(OTf)2 (20 mol%) and Ag2O (1.0 eq.) is described. Later, ortho-arylated acetanilides were converted into phenanthridine and carbazole derivatives by using Ph3PO and Tf2O or palladium or Cu(OTf)2 catalysts.
摘要
本文描述了在 Ru(II) 配合物（3 mol%）、AgSbF6（12 mol%）、Cu(OTf)2（20 mol%）和 Ag2O（1.0 eq.）存在的条件下，芳基硼酸对乙酰苯胺的高区域选择性邻位芳基化反应。随后，使用 Ph3PO 和 Tf2O 或钯或 Cu(OTf)2 催化剂，将邻位芳基化的乙酰苯胺转化为菲啶和咔唑衍生物。
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