Division of Cancer Prevention Research, National Cancer Center Research Institute, 1-1, Tsukiji 5-chome, Chuo-ku, Tokyo 104-0045, Japan.
Anticancer Res. 2013 Sep;33(9):3667-74.
Helicobacter pylori (Hp) infection causes gastritis and is considered a gastric cancer risk factor. We have previously reported that codfish meal markedly enhanced Hp-induced gastritis in Mongolian gerbils. In the present study, we sought the responsible components in codfish meal.
Codfish were divided into three parts (meat, viscera and 'other parts', including bone), and administered to Hp-infected gerbils. Subsequently, cod bone, sardine bone and prawn shell were tested, along with major calcium components, hydroxyapatite and calcium carbonate, in bone and shell, respectively.
'Other parts' and cod bone enhanced Hp-induced gastritis, as was observed for whole codfish. Similarly, sardine bone and prawn shell, as well as 0.22-0.88% hydroxyapatite and calcium carbonate, enhanced gastritis. In contrast, administration of a higher dose of the calcium compounds exerted protective effects.
Intake of calcium compounds may contribute to enhancement of Hp-induced gastritis.
幽门螺杆菌（Hp）感染会导致胃炎，被认为是胃癌的一个危险因素。我们之前曾报道过，鳕鱼粉显著增强了蒙古沙土鼠的 Hp 诱导性胃炎。在本研究中，我们探寻了鳕鱼粉中的致病成分。
将鳕鱼分为三个部分（肉、内脏和“其他部分”，包括骨头），并喂食给感染了 Hp 的沙土鼠。随后，我们测试了鳕鱼骨、沙丁鱼骨和对虾壳，以及骨和壳中的主要钙成分羟磷灰石和碳酸钙。
“其他部分”和鳕鱼骨增强了 Hp 诱导的胃炎，就像整条鳕鱼一样。同样，沙丁鱼骨和对虾壳，以及 0.22-0.88%的羟磷灰石和碳酸钙，也增强了胃炎。相比之下，服用更高剂量的钙化合物则具有保护作用。
钙化合物的摄入可能会导致 Hp 诱导性胃炎的加重。
