Tanigawa T, Kawamori T, Iimuro M, Ohta T, Higuchi K, Arakawa T, Sugimura T, Wakabayashi K
Cancer Prevention Division, National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan.
Jpn J Cancer Res. 2000 Aug;91(8):769-73. doi: 10.1111/j.1349-7006.2000.tb01011.x.
In a search for dietary factors influencing Helicobacter pylori-induced gastritis, the effects of fish meal in the diet were examined in Mongolian gerbils. When a conventional diet containing 10% fish meal was given to Mongolian gerbils for 4 weeks after inoculation of H. pylori, edematous thickening with severe neutrophil and mononuclear cell infiltration in both the mucosa and submucosa was observed in the glandular stomach of 19 out of the 20 animals, and hemorrhagic spots were evident in 11 cases. These gastric lesions were enhanced by a 20% fish meal supplement, and edema and hemorrhage in the gastric mucosa were observed in 19 and 17 out of 20 animals, respectively. Although almost the same levels of viable bacteria were detected independent of the diet, edema and hemorrhage were seen in only 2 and 1 of 20 gerbils fed a diet containing 10% casein, instead of 10% fish meal, respectively. Neither edema nor hemorrhage was observed in 10% beef diet animals. These results suggest that fish meal contains factors which greatly enhance H. pylori-induced gastritis in Mongolian gerbils. Since the incidences of gastritis and gastric cancer are very high throughout the world, it is very important to identify these gastritis-enhancing factors.
在探寻影响幽门螺杆菌诱发胃炎的饮食因素时，研究人员在蒙古沙鼠身上检测了鱼粉在饮食中的作用。在给接种幽门螺杆菌后的蒙古沙鼠喂食含10%鱼粉的常规饮食4周后，20只动物中有19只的腺胃出现黏膜和黏膜下层水肿增厚，伴有严重的中性粒细胞和单核细胞浸润，11例出现出血点。补充20%鱼粉会加剧这些胃部病变，20只动物中分别有19只和17只出现胃黏膜水肿和出血。尽管无论饮食如何，检测到的活菌数量几乎相同，但喂食含10%酪蛋白而非10%鱼粉饮食的20只沙鼠中，分别只有2只和1只出现水肿和出血。喂食10%牛肉饮食的动物未出现水肿和出血。这些结果表明，鱼粉中含有能极大加剧蒙古沙鼠幽门螺杆菌诱发胃炎的因素。鉴于胃炎和胃癌在全球的发病率都很高，识别这些加剧胃炎的因素非常重要。
