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老年男性中罕见的肺胚细胞瘤双相型。

A rare occurrence of biphasic pulmonary blastoma in an elderly male.

机构信息

Department of Medical Oncology, Mount Vernon Cancer Centre, Rickmansworth Road, Northwood, Middlesex, HA6 2RN, U.K.

出版信息

Anticancer Res. 2013 Sep;33(9):3911-5.

Abstract

Pulmonary Blastoma (PB) is a rare primary lung malignancy usually occurring in young to middle aged adults. Surgery is the primary mode of treatment, but survival is poor with the mean 5-year survival being approximately 16%. We report on a case of PB arising in a 63-year-old man. Computed tomography, magnetic resonance imaging and positron emission tomography confirmed the mass to be of pulmonary origin. The morphological appearance combined with the immunoprofile of the tumour was consistent with a poorly-differentiated biphasic pulmonary blastoma. Two months after the surgical resection the patient relapsed with multiple sites of metastasis. The patient was treated with four cycles of cyclophosphamide-, doxorubicin- and vincristine-(CAV)-based chemotherapy, achieving a partial response to treatment. He is currently on a two-monthly review and is recovering from chemotherapy-related toxicities.

摘要

肺胚细胞瘤(PB)是一种罕见的原发性肺部恶性肿瘤,通常发生在年轻到中年成年人中。手术是主要的治疗方式,但存活率低,平均 5 年生存率约为 16%。我们报告了一例发生在 63 岁男性的 PB 病例。计算机断层扫描、磁共振成像和正电子发射断层扫描证实该肿块源自肺部。肿瘤的形态外观和免疫表型与低分化的双相性肺胚细胞瘤一致。手术切除两个月后,患者出现多处转移复发。患者接受了四个周期的环磷酰胺、多柔比星和长春新碱(CAV)为基础的化疗,治疗后达到部分缓解。目前他每两个月进行一次复查,正在从化疗相关毒性中恢复。

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