Bahar Adele, Akha Ozra, Kashi Zahra, Vesgari Zakiie
Department of Internal Medicine, Imam Khomeini Hospital, Mazandaran University of Medical, Sciences, Sari, Iran.
Caspian J Intern Med. 2011 Spring;2(2):229-33.
Hyperprolactinemia is the most common endocrine disorder in hypothalamic-pituitary axis and has been reported in variable levels in patients with overt primary hypothyroidism. We decided to determine the prevalence of hyperprolactinemia and clinical related symptoms in subclinical hypothyroidism patients.
In this cross sectional study, prolactin levels of 481 subclinical hypothyroid patients were assessed. Prolactin measurement was performed using chemiluminescent immunoassay. Data were collected and analyzed.
Sixty-two (13%) patients were males and 419 (87%) were females. The mean age of the patients was 32.53±10.13 years. Ninty-eight patients (91 females 7 males) had high prolactin. Prevalence of hyperprolactinemia in subclinical hypothyroidism was 20.4%. (11% in men and 22% in women, p=0.05). There was no correlation between the serum TSH and prolactin level. Clinical symptom prevalence was not different between patients with and without hyperprolactinemia.
This study showed that prevalence of hyperprolactinemia in subclinical hypothyroidism is notable and this disorder is more common in female subclinical hypothyroidism than the men.
高催乳素血症是下丘脑 - 垂体轴最常见的内分泌紊乱疾病，据报道，显性原发性甲状腺功能减退症患者中该疾病的水平各不相同。我们决定确定亚临床甲状腺功能减退症患者中高催乳素血症的患病率及临床相关症状。
在这项横断面研究中，对481例亚临床甲状腺功能减退症患者的催乳素水平进行了评估。采用化学发光免疫分析法进行催乳素测定。收集并分析数据。
62例（13%）患者为男性，419例（87%）为女性。患者的平均年龄为32.53±10.13岁。98例患者（91例女性，7例男性）催乳素水平升高。亚临床甲状腺功能减退症患者中高催乳素血症的患病率为20.4%。（男性为11%，女性为22%，p = 0.05）。血清促甲状腺激素（TSH）与催乳素水平之间无相关性。有高催乳素血症和无高催乳素血症的患者临床症状患病率无差异。
本研究表明，亚临床甲状腺功能减退症患者中高催乳素血症的患病率值得关注，且该疾病在女性亚临床甲状腺功能减退症患者中比男性更常见。
