一种高度选择性的人细胞色素 P450 3A4 探针：亚型选择性、动力学特征及其应用。
A highly selective probe for human cytochrome P450 3A4: isoform selectivity, kinetic characterization and its applications.
机构信息
Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.
出版信息
Chem Commun (Camb). 2013 Oct 28;49(84):9779-81. doi: 10.1039/c3cc45250f.
PMID:24026006
Abstract
Bufalin 5β-hydroxylation was found to be an isoform-specific biotransformation probe substrate for cytochrome P450 3A4 (CYP3A4). The probe reaction was well-characterized and it can be used for measuring the real catalytic activities of CYP3A4 from different enzyme sources.
摘要
蟾毒灵 5β-羟化被发现是细胞色素 P450 3A4（CYP3A4）的同工型特异性生物转化探针底物。该探针反应具有良好的特征，可以用于测量来自不同酶源的 CYP3A4 的真实催化活性。
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