The Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Sha Tin, Hong Kong, China.
Psychooncology. 2014 Feb;23(2):229-36. doi: 10.1002/pon.3396. Epub 2013 Sep 12.
Previous literatures on young adult survivors of childhood cancer show inconsistent findings with regards to their psychological distress and health-related quality of life (HRQOL). Much of the available data focus on negative patient outcomes following cancer treatments prescribed from 1970 to 1990. In the present study, HRQOL and psychological distress of young adult survivors in Hong Kong was examined. It focused on subjects who had received cancer treatments prescribed in the last two decades.
A structured telephone survey was conducted with 614 eligible survivors and 208 sibling controls in Hong Kong.
The survivors reported significantly lower mean scores in physical role and functioning, whereas their mental, social, and psychological well-being was similar to that of their sibling controls. Being female, older age, longer survival time, and specific cancer diagnoses were the factors associated with poorer physical and mental adaptation. HRQOL was negatively correlated with psychological distress.
Findings of the study suggest that most survivors adjusted fairly well in mental, psychological, and social aspects. Survivors with a higher risk of poor HRQOL could benefit from appropriate screening and counseling at an early stage to mitigate their survivorship difficulties. Prospective follow-up studies on childhood cancer survivors are recommended to detect changes over longer survival periods.
既往研究显示，儿童癌症幸存者在心理困扰和健康相关生活质量（HRQOL）方面的结果存在不一致。大多数现有数据集中于对 20 世纪 70 年代至 90 年代治疗方案的研究，而本研究则聚焦于近二十年治疗方案的儿童癌症幸存者。
本研究采用结构式电话调查，对香港地区 614 名符合条件的幸存者和 208 名同胞对照进行了调查。
幸存者的生理角色和功能评分显著较低，而他们的精神、社会和心理幸福感与同胞对照相似。女性、年龄较大、生存时间较长以及特定癌症诊断是与较差的生理和心理适应相关的因素。HRQOL 与心理困扰呈负相关。
本研究结果表明，大多数幸存者在精神、心理和社会方面适应得相当好。对于 HRQOL 较差的高危幸存者，早期进行适当的筛查和咨询可以减轻他们的生存困难。建议开展儿童癌症幸存者的前瞻性随访研究，以检测更长生存时间的变化。
