Meeske K A, Ruccione K, Globe D R, Stuber M L
Long-Term Information, Follow-up and Evaluation (LIFE) Program, Childrens Center for Cancer and Blood Diseases, Childrens Hospital Los Angeles, USA.
Oncol Nurs Forum. 2001 Apr;28(3):481-9.
PURPOSE/OBJECTIVES: To explore the relationship between posttraumatic stress disorder (PTSD) and quality of life (QOL)/psychological outcome in young adult survivors of childhood cancer.
Cross-sectional, descriptive study.
A large comprehensive pediatric cancer center on the West Coast.
Fifty-one young adult survivors of childhood cancer, 18-37 years of age, disease free, and off treatment for an average of 11 years (range 2.8-26.7 years).
A structured clinical interview was used to establish a PTSD diagnosis. Self-report instruments were used to assess QOL (RAND SF-36) and psychological distress (Brief Symptom Inventory (BSI)). Survivors with and without PTSD were compared on the BSI and RAND SF-36.
PTSD status, QOL and psychological distress.
Eleven subjects (20%) met full criteria for PTSD. Significant group differences were found for 17 of the 18 outcome variables. Survivors with PTSD reported clinically significant levels of psychological distress, whereas symptom levels for those without PTSD fell well within population norms. On all domains, QOL scores were significantly lower for the PTSD group compared to the non-PTSD group.
PTSD in survivors of childhood cancer is related to long-term outcome. PTSD is associated with a poorer QOL (physical and mental) and an increase in psychological distress. Data suggest that survivors with PTSD have significant functional limitations and psychological comorbidity.
Screening cancer survivors for PTSD will identify high-risk patients who need further evaluation and intervention.
目的/目标：探讨儿童癌症成年幸存者创伤后应激障碍（PTSD）与生活质量（QOL）/心理结局之间的关系。
横断面描述性研究。
西海岸一家大型综合性儿科癌症中心。
51名儿童癌症成年幸存者，年龄在18至37岁之间，无疾病，平均停止治疗11年（范围2.8至26.7年）。
采用结构化临床访谈来确定PTSD诊断。使用自我报告工具评估生活质量（RAND SF - 36）和心理困扰（简明症状量表（BSI））。比较有和没有PTSD的幸存者在BSI和RAND SF - 36上的情况。
PTSD状态、生活质量和心理困扰。
11名受试者（20%）符合PTSD的全部标准。在18个结局变量中的17个发现了显著的组间差异。患有PTSD的幸存者报告了临床上显著的心理困扰水平，而没有PTSD的幸存者的症状水平则完全在人群正常范围内。在所有领域，与非PTSD组相比，PTSD组的生活质量得分显著更低。
儿童癌症幸存者中的PTSD与长期结局相关。PTSD与较差的生活质量（身体和心理方面）以及心理困扰增加有关。数据表明，患有PTSD的幸存者存在显著的功能限制和心理共病。
对癌症幸存者进行PTSD筛查将识别出需要进一步评估和干预的高危患者。
