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A B cell-suppressive IgG-antiimmunoglobulin antibody induced by alloimmunization.

作者信息

Terness P, Süsal C, Baur C, Guo Z G, Opelz G

机构信息

Department of Transplantation Immunology, University of Heidelberg, Federal Republic of Germany.

出版信息

Transplantation. 1990 Sep;50(3):502-5. doi: 10.1097/00007890-199009000-00028.

DOI:10.1097/00007890-199009000-00028
PMID:2402797
Abstract

This study is an extension of our previous report that alloimmunization produces a serum factor that suppresses the lymphocytotoxic antibody response. The experiments presented herein show that: (1) serum and IgG of pretreated rats contain an antibody directed against the constant region of IgG; (2) the anti-IgG has strong anti-Fc-gamma and weak anti-Fab activity; (3) the antibody also reacts with IgM; (4) the antiimmunoglobulin is an autoantibody; and (5) the antiimmunoglobulin suppresses the primary B cell response in vitro.

摘要

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