Terness P, Schiffl R, Süsal C, Guo Z G, Opelz G
Institute of Immunology, University of Heidelberg, F.R.G.
Immunol Lett. 1990 Nov;26(2):139-44. doi: 10.1016/0165-2478(90)90136-e.
Treatment of LEW rats before transplantation with BN blood cells preincubated with LEW-anti-BN serum resulted in prolonged BN kidney graft survival (untreated, 8 +/- 0.4 days; pretreated, 124 +/- 36). The serum of pretreated animals contains a factor which suppresses T cell proliferation against donor antigens. This effect was not mediated by antiidiotypic antibodies because it was reproduced in a donor-unrelated system. The serum and IgG of pretreated animals also suppressed the humoral immune response. As for T cells, the antibody-suppressive effect was not donor-restricted. A broadly reactive anti-immunoglobulin (anti-B cell) autoantibody was found in the IgG fraction of immunized animals. The mediation of immunosuppression by broadly reactive anti-B and T cell autoantibodies induced by the immunization with antibody-coated blood cells is discussed.
用与LEW抗BN血清预孵育的BN血细胞对LEW大鼠进行移植前处理，可延长BN肾移植的存活时间（未处理组，8±0.4天；预处理组，124±36天）。预处理动物的血清中含有一种抑制T细胞针对供体抗原增殖的因子。这种效应不是由抗独特型抗体介导的，因为在与供体无关的系统中也能重现。预处理动物的血清和IgG也抑制体液免疫反应。至于T细胞，抗体抑制作用不受供体限制。在免疫动物的IgG组分中发现了一种广泛反应性的抗免疫球蛋白（抗B细胞）自身抗体。本文讨论了用抗体包被的血细胞免疫诱导的广泛反应性抗B细胞和T细胞自身抗体介导免疫抑制的机制。
