School of Electronics and Computer Science, University of Southampton, Southampton SO17 1BJ, United Kingdom.
Comput Methods Programs Biomed. 2013 Dec;112(3):490-507. doi: 10.1016/j.cmpb.2013.08.012. Epub 2013 Aug 30.
In this paper, an incommensurate fractional order (FO) model has been proposed to generate ECG like waveforms. Earlier investigation of ECG like waveform generation is based on two identical Van-der Pol (VdP) family of oscillators, which are coupled by time delays and gains. In this paper, we suitably modify the three state equations corresponding to the nonlinear cross-product of states, time delay coupling of the two oscillators and low-pass filtering, using the concept of fractional derivatives. Our results show that a wide variety of ECG like waveforms can be simulated from the proposed generalized models, characterizing heart conditions under different physiological conditions. Such generalization of the modelling of ECG waveforms may be useful to understand the physiological process behind ECG signal generation in normal and abnormal heart conditions. Along with the proposed FO models, an optimization based approach is also presented to estimate the VdP oscillator parameters for representing a realistic ECG like signal.
本文提出了一种非齐次分数阶(FO)模型来生成类似心电图的波形。早期的类似心电图波形生成研究基于两个相同的范德波尔(VdP)家族振荡器,它们通过时滞和增益耦合。在本文中,我们使用分数导数的概念,适当修改了对应于状态非线性乘积、两个振荡器的时滞耦合和低通滤波的三个状态方程。我们的结果表明,从提出的广义模型中可以模拟出各种各样的类似心电图的波形,这些波形可以描述不同生理条件下的心脏状况。这种对心电图波形建模的推广可能有助于理解正常和异常心脏条件下心电图信号产生背后的生理过程。本文还提出了一种基于优化的方法来估计 VdP 振荡器参数,以表示一个现实的类似心电图信号。