Shah Niraj M, Rushworth Stuart A, Murray Megan Y, Bowles Kristian M, MacEwan David J
Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, United Kingdom.
Oncotarget. 2013 Aug;4(8):1130-42. doi: 10.18632/oncotarget.1181.
Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is a key transcription factor that regulates the expression of over a hundred cytoprotective and antioxidant genes that provide cellular protection from reactive oxygen species. Chemotherapy resistance in several cancers has been linked to dysregulation of the NRF2 signalling pathway, moreover there is growing evidence that NRF2 may contribute to tumorigenesis. MicroRNA (miRNA) are small non-coding RNA sequences that post-transcriptionally regulate mRNA sequences. In cancer pathogenesis, aberrantly expressed miRNAs can act as either tumor suppressor or oncogenic miRNA. Recent evidence has been described that identifies a number of miRNA that can be regulated by NRF2. This review outlines the importance of NRF2 in regulating miRNA, and the functional role this may have in the tumorigenesis of human malignancies and their chemotherapy resistance.
核因子（红系衍生2）样2（NRF2）是一种关键的转录因子，可调节一百多种细胞保护和抗氧化基因的表达，这些基因可保护细胞免受活性氧的伤害。几种癌症中的化疗耐药性与NRF2信号通路失调有关，此外，越来越多的证据表明NRF2可能促进肿瘤发生。微小RNA（miRNA）是小的非编码RNA序列，可在转录后调节mRNA序列。在癌症发病机制中，异常表达的miRNA可作为肿瘤抑制性miRNA或致癌性miRNA。最近有证据表明，一些miRNA可受NRF2调控。本综述概述了NRF2在调节miRNA中的重要性，以及这在人类恶性肿瘤的肿瘤发生及其化疗耐药性中可能具有的功能作用。
