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[血液吸附、血浆置换和肠吸附在天疱疮中的免疫纠正和解毒作用]

[The immunocorrective and detoxifying actions of hemosorption, plasmapheresis and enterosorption in pemphigus].

作者信息

Grebennikov V A, Beliaevskiĭ A D, Kaminskiĭ M Iu, Kuzina Z A, Litvinenko T A

出版信息

Vestn Dermatol Venerol. 1990(5):33-8.

PMID:2402939
Abstract

Immunity system changes and intoxication characteristics were studied in two groups of patients with pemphigus treated with traditional methods (group 1, 14 patients) and routine therapy combined with hemoperfusion, plasmapheresis, and enterosorption (group 2, 12 patients). During exacerbation pemphigus patients develop manifest changes in the immunity status in the presence of endotoxicosis. Introduction of hemoperfusion, plasmapheresis, and enterosorption in the complexes of treatment of pemphigus patients activates erosion epithelialization, helps sooner reduce the doses of corticosteroids whose total dose is reduced by 39 percent, improves cell-mediated and humoral immunity parameters, and is conducive to a more favorable time course of the body intoxication parameters.

摘要

对两组天疱疮患者的免疫系统变化和中毒特征进行了研究。一组采用传统方法治疗(第1组,14例患者),另一组采用常规治疗并结合血液灌流、血浆置换和肠吸附(第2组,12例患者)。在病情加重期间,天疱疮患者在内毒素血症存在的情况下会出现明显的免疫状态变化。在天疱疮患者的治疗方案中引入血液灌流、血浆置换和肠吸附,可激活糜烂上皮化,有助于更快减少皮质类固醇的剂量,其总剂量可降低39%,改善细胞介导和体液免疫参数,并有利于身体中毒参数的更有利病程。

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