奥沙利铂诱导的消化道肿瘤神经病变
Oxaliplatin induced-neuropathy in digestive tumors.
作者信息
Sereno María, Gutiérrez-Gutiérrez Gerardo, Gómez-Raposo César, López-Gómez Miriam, Merino-Salvador Maria, Tébar Francisco Zambrana, Rodriguez-Antona Cristina, Casado Enrique
机构信息
Medical Oncologist, Medical Oncology Department, Infanta Sofía University Hospital, San Sebastian de los Reyes, Madrid 28702, Spain.
Neurologist, Neuromuscular Unit, Neurology Department, Infanta Sofía University Hospital, San Sebastian de los Reyes, Madrid 28702, Spain.
出版信息
Crit Rev Oncol Hematol. 2014 Jan;89(1):166-78. doi: 10.1016/j.critrevonc.2013.08.009. Epub 2013 Aug 28.
Oxaliplatin is one of the main drugs used in digestive tumors treatment. Peripheral neuropathy is a well-recognized dose-limiting toxicity of OXL. Two types of neuropathy have been described with this agent: acute or transient and chronic or persistent, with different etiology, clinical manifestations and prognosis. This paper is an exhaustive review about the main aspects of oxaliplatin induced peripheral neuropathy, focus in clinical features, treatment, prevention strategies and future approach.
奥沙利铂是用于治疗消化系统肿瘤的主要药物之一。外周神经病变是奥沙利铂一种公认的剂量限制性毒性。使用该药物已描述了两种类型的神经病变：急性或短暂性以及慢性或持续性，它们具有不同的病因、临床表现和预后。本文是关于奥沙利铂所致外周神经病变主要方面的详尽综述，重点在于临床特征、治疗、预防策略及未来方向。
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