Department of Neurological Sciences, Rush University Medical Center, Chicago, Ill., USA.
Neurodegener Dis. 2014;13(2-3):151-3. doi: 10.1159/000353687. Epub 2013 Sep 11.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of extracellular amyloid-β peptide and intracellular tau. Here, we review data suggesting that prefibrillar tau oligomers mediate cognitive decline early in the disease.
It was our aim to study the presence of tau-positive pretangle neurons and correlate findings with cognitive test scores.
Pretangle antibodies (TOC1 and pS422) were applied to tissue containing cholinergic basal forebrain neurons from people who died with a premortem clinical diagnosis of no cognitive impairment, mild cognitive impairment and AD.
Data lend support to the concept that tau oligomers are the toxic form of tau, that non-fibillar tau relates to cognitive dysfunction and that the earliest pretangle pathology occurs in neuritic processes.
Clinicopathological findings highlight the importance of studying tau modifications in neuronal soma and neuritic processes, which may be the earliest pathological lesions that correlate with cognitive status.
阿尔茨海默病（AD）是一种进行性神经退行性疾病，其特征是细胞外淀粉样β肽和细胞内 tau 的积累。在这里，我们回顾了一些数据，这些数据表明，原纤维前 tau 寡聚体在疾病早期介导认知能力下降。
我们的目的是研究存在 tau 阳性 pretangle 神经元，并将研究结果与认知测试评分相关联。
使用 pretangle 抗体（TOC1 和 pS422）对含有胆碱能基底前脑神经元的组织进行检测，这些组织来自于生前临床诊断为无认知障碍、轻度认知障碍和 AD 的人。
数据支持 tau 寡聚体是 tau 的毒性形式的观点，非纤维状 tau 与认知功能障碍有关，最早的 pretangle 病理学发生在神经突过程中。
临床病理发现强调了研究神经元胞体和神经突中 tau 修饰的重要性，这可能是与认知状态相关的最早的病理病变。
