From the Department of Imaging, Hospital Lapeyronie (I.M., F.C., E.B., X.P., C.A., P.T.), and Department of Statistics (N.M.), Centre Hospitalo-Universitaire Montpellier, 371 Avenue du Doyen Gaston Giraud, Montpellier 34295, France; and CIC INSERM 1001, University of Montpellier I, Montpellier, France (I.M., P.T.).
Radiology. 2014 Jan;270(1):57-66. doi: 10.1148/radiol.13122758. Epub 2013 Oct 28.
To retrospectively compare the kinetic magnetic resonance (MR) imaging characteristics of invasive breast carcinomas with both prognostic tumoral and patient-related parameters.
This HIPAA-compliant retrospective study was approved by the institutional review board, and informed consent was waived. From January 2008 to January 2011, 273 consecutive women (mean age, 55 years; range, 23-83 years) with invasive breast cancers who had undergone MR imaging were selected. The kinetic curves were retrospectively classified according to the Breast Imaging Reporting and Data System lexicon. Initial enhancement and maximal enhancement percentages, time to peak enhancement, and the signal enhancement ratio were calculated for each lesion. Kinetic characteristics were compared according to tumoral parameters (size, pathologic type, grade, hormone receptor status, and c-erbB-2 status) and patient parameters (menopausal status, personal history of breast carcinoma) by means of univariate and then multivariate analysis by using false-discovery-rate statistics.
Lesions in menopausal patients exhibited less suspicious quantitative and qualitative characteristics than lesions in nonmenopausal patients. There was an independent association between the kinetic characteristics and menopausal status, with an odds ratio of 2.94 for the lack of rapid initial contrast material uptake and of 2.38 for the lack of washout in menopausal patients as compared with nonmenopausal patients. The odds ratio was 4.00 for not having rapid initial contrast material uptake in patients with a personal history of ipsilateral breast cancer.
Kinetic data in invasive breast cancer are associated with the patient's menopausal status, with a typical kinetic pattern of malignancy being less common in menopausal patients.
回顾性比较具有预后肿瘤和患者相关参数的浸润性乳腺癌的磁共振（MR）动力学成像特征。
该 HIPAA 兼容的回顾性研究经机构审查委员会批准，且豁免了知情同意。2008 年 1 月至 2011 年 1 月，选择了 273 例连续接受 MR 成像检查的浸润性乳腺癌女性患者（平均年龄 55 岁；范围，23-83 岁）。根据乳腺成像报告和数据系统词汇表，对动力学曲线进行回顾性分类。为每个病变计算初始增强和最大增强百分比、达到峰值增强的时间和信号增强比。通过单变量和然后通过错误发现率统计进行多变量分析，根据肿瘤参数（大小、病理类型、分级、激素受体状态和 c-erbB-2 状态）和患者参数（绝经状态、个人乳腺癌病史）比较动力学特征。
绝经患者的病变比未绝经患者的病变表现出较少的可疑定量和定性特征。动力学特征与绝经状态之间存在独立关联，绝经患者快速初始对比剂摄取不足和洗脱不足的比值比分别为 2.94 和 2.38。与未绝经患者相比，有同侧乳腺癌个人病史的患者快速初始对比剂摄取不足的比值比为 4.00。
浸润性乳腺癌的动力学数据与患者的绝经状态相关，绝经患者的典型恶性动力学模式不太常见。
