Gastroenterology Department, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey.
Med Sci Monit. 2013 Sep 13;19:762-6. doi: 10.12659/MSM.889068.
The aim of this study was to evaluate the plasma concentrations of malondialdehyde (MDA) and nitric oxide (NO) and the plasma activities of oxidant and antioxidant enzymes in patients with IBS.
MATERIAL/METHODS: A total of 36 patients with IBS were included in the study. Thirty-five healthy subjects were selected to form the control group. Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), xanthine oxidase (XO), adenosine deaminase (AD) activities, and malondialdehyde (MDA) and nitric oxide (NO) concentrations were studied in the serum samples of all patients and controls.
Plasma XO and AD activities, and MDA and NO concentrations were significantly higher in IBS patients than in controls. The SOD, CAT, and GSH-Px activities in the serum of patients with IBS were significantly lower than that of controls.
These results suggest that lipid peroxidation and alterations in the oxidant-antioxidant enzymatic system may play a role in the pathogenesis of IBS. Increased lipid peroxidation in IBS may be related to an increase in NO level and XO activity and a decrease in antioxidant enzymes activities. In addition, increased AD activity may have a role in immunological changes of IBS patients.
本研究旨在评估 IBS 患者的血浆丙二醛（MDA）和一氧化氮（NO）浓度以及氧化应激和抗氧化酶的血浆活性。
材料/方法：共纳入 36 例 IBS 患者，选择 35 例健康受试者作为对照组。检测所有患者和对照组血清中超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GSH-Px）、黄嘌呤氧化酶（XO）、腺苷脱氨酶（AD）的活性以及 MDA 和 NO 的浓度。
与对照组相比，IBS 患者的血浆 XO 和 AD 活性以及 MDA 和 NO 浓度显著升高。IBS 患者血清中的 SOD、CAT 和 GSH-Px 活性明显低于对照组。
这些结果表明，脂质过氧化和氧化应激酶系统的改变可能在 IBS 的发病机制中起作用。IBS 中脂质过氧化的增加可能与 NO 水平和 XO 活性的增加以及抗氧化酶活性的降低有关。此外，AD 活性的增加可能与 IBS 患者的免疫变化有关。
